I still use two strands over one on it. In fact, I did a Kinkade on 32 ct with two over one, & it turned out beautiful. That one had half crosses in it too. I like the effect that using two over one gives. My eyes get tired, so I believe I will only go 25 or 28 ct over one from now on.
Never did a pattern on the higher count that had any quarter stitches though, only full, or half crosses. I believe on that small count, you could get away without doing quarter stitches, & it would not be noticeable. That's just my opinion though.